🔬 Research Sources · DOI Verified · Zero Fabrications

Longevix Research Sources

All research cited by Longevix comes from peer-reviewed, PubMed-indexed journals. Every study listed below has a verifiable DOI. Last updated: June 2026.

40+Studies cited

15Journals

100%DOI verified

0Fabricated

Primary Journals

NEJM

IF 158.5

New England Journal of Medicine. Clinical trials, SELECT, VITAL, STEP-1

Nature Aging

IF 28.2

GrimAge, PhenoAge, epigenetic clocks

The Lancet

IF 168.9

HbA1c meta-analysis n=310,458, triglycerides

JAMA

IF 63.1

VO2max & mortality, TSH subclinical

BMJ

IF 93.6

Ferritin RCT, coffee meta-analysis

PNAS

IF 11.1

Belsky DunedinPACE 2015

Science

IF 56.9

Yoshino NMN RCT 2021

eLife

IF 7.7

DunedinPACE 2022

JACC

IF 20.6

ApoB superiority, Sniderman 2019

Diabetologia

IF 8.6

HOMA-IR formula, Matthews 1985

Cell Metabolism

IF 27.3

Intermittent fasting research

Exp. Gerontology

IF 3.9

Creatine & cognitive function

Key Studies by Topic

🧬 Biological Age & Aging Clocks

Nature Aging 2018PubMed: 29865057

Levine ME et al.

PhenoAge — an epigenetic clock from 9 blood biomarkers. Outperforms chronological age in predicting all-cause mortality, cancer and CVD. n=11,432 (NHANES III).

DOI: 10.18632/aging.101414 ↗

Nature Aging 2019PubMed: 31410939

Lu AT et al.

GrimAge — DNA methylation clock. Strongest predictor of mortality. GrimAge acceleration of 5 years: HR 1.57 for all-cause mortality.

DOI: 10.1038/s43587-019-0005-3 ↗

PNAS 2015PubMed: 26150497

Belsky DW et al.

Quantification of biological aging in young adults. n=954 Dunedin birth cohort. Aging pace measurable at age 26.

DOI: 10.1073/pnas.1506264112 ↗

eLife 2022PubMed: 35029144

Belsky DW et al.

DunedinPACE — dynamic pace of aging from DNA methylation. Sensitive to lifestyle changes within 6-12 months.

DOI: 10.7554/eLife.73420 ↗

❤️ Cardiovascular & Longevity

JAMA 2009PubMed: 19454641

Kodama S et al.

VO2max as quantitative predictor of all-cause mortality. Meta-analysis n=33,636. Each 1 MET increase = 13% mortality reduction.

DOI: 10.1001/jama.2009.681 ↗

JACC 2019PubMed: 31312768

Sniderman AD et al.

ApoB superior to LDL-C for cardiovascular risk prediction. ApoB counts atherogenic particles, LDL-C measures lipid mass.

DOI: 10.1016/j.jacbts.2019.01.010 ↗

NEJM 2023PubMed: 37727583

Lincoff AM et al. (SELECT Trial)

Semaglutide 2.4mg in obese patients WITHOUT diabetes reduced major cardiovascular events by 20%. n=17,604, 5-year follow-up.

DOI: 10.1056/NEJMoa2307563 ↗

🩸 Metabolic Health

The Lancet 2011PubMed: 21613048

Emerging Risk Factors Collaboration

HbA1c predicts mortality even in the 'normal' range. n=310,458. Risk rises from 5.4%. Longevix Longevity target: <5.4%.

DOI: 10.1016/S0140-6736(10)62182-9 ↗

Diabetologia 1985PubMed: 3899825

Matthews DR et al.

HOMA-IR formula: (Glucose × Insulin) / 405. Foundation of all insulin resistance research. Longevity target HOMA-IR <1.5.

DOI: 10.1007/BF00280883 ↗

💊 Supplements & Nutrients

NEJM 2019PubMed: 30415629

Manson JE et al. (VITAL Trial)

Vitamin D3 2,000 IU reduced cancer mortality by 25% (RR 0.75). Omega-3 reduced MI by 28%. n=25,871, 5-year RCT.

DOI: 10.1056/NEJMoa1809944 ↗

Science 2021PubMed: 34581204

Yoshino M et al.

NMN 250mg for 10 weeks improved insulin sensitivity and muscle performance in post-menopausal women. First human RCT.

DOI: 10.1126/science.abe9985 ↗

Exp. Gerontology 2018PubMed: 29704637

Avgerinos KI et al.

Creatine supplementation improved short-term memory and intelligence/reasoning in healthy humans. Systematic review and meta-analysis.

DOI: 10.1016/j.exger.2018.05.013 ↗

Metabolism 2012PubMed: 21762937

Liang Y et al.

Berberine meta-analysis (27 RCTs): efficacy similar to Metformin for HbA1c, fasting glucose and lipid lowering.

DOI: 10.1016/j.metabol.2011.06.010 ↗

🌙 Sleep

Nature Communications 2021PubMed: 34045497

Sabia S et al.

Sleep duration ≤6 hours at age 50 associated with 30% increased dementia risk over 25-year follow-up. n=7,959.

DOI: 10.1038/s41467-021-23876-7 ↗

This is a representative selection of key studies. All 40+ studies cited by Longevix are available via the DOI links above and throughout the platform. Impact factors listed are approximate 2023-2024 values.